Elevated Urinary Pepsinogen: A Subclinical Marker of Ulcer Diathesis

Serum pepsinogen, a genetic marker in duodenal ulcer.

Study of duodenal ulcer disease in 100 families using total serum pepsinogen as a genetic marker.

Although various markers have been used in attempts to elucidate the mode of inheritance of duodenal ulcer, they have not significantly contributed to a clear understanding of the problem. In the present study total serum pepsinogen was used as a genetic marker and its concentrations were estimated in 100 ulcer patients and their family members up to three generations. Eighty three per cent of ...

Role of serum pepsinogen in detecting cows with abomasal ulcer

Serum pepsinogen activity was determined in the blood serum of 126 clinically healthy cows by the method of Paynter. After slaughter the cows studied were classified into three groups according to established macroscopic changes to the mucous membrane of the abomasum: a group without changes, a group with ulcers and a group with other changes. The prevalence of the appearance of abomasal ulcers...

Serum pepsinogen I concentrations in peptic ulcer patients in relation to ulcer location and stage.

To investigate the relation of the serum group I pepsinogen (PG I) concentration to the location of gastric ulcers and chronicity of peptic ulcers, ulcer patients (n = 322) were compared with endoscopically normal subjects (n = 174). The mean PG I concentration was significantly higher in male control subjects (n = 90) than in female control subjects (n = 84). In male patients with ulcers in th...

Pepsinogen C gene polymorphisms associated with gastric body ulcer.

This study was aimed to investigate the association of restriction fragment length polymorphisms (RFLPs) for pepsinogen genes with peptic ulcer disease. Eighty unrelated controls, 61 patients with gastric ulcer, and 57 patients with duodenal ulcer were studied. No genetic polymorphisms for pepsinogen A were detected by EcoRI digestion in Japanese subjects but a 100 base pairs insertion-deletion...